Dusting Powder Presentation

TERBINAFINE 1% W/W 50g

Terbinafine belongs to allylamine class of antifungal drugs. It works by weakening the fungal cell membrane. It mainly indicated for the treatment of nail and nail infections. It has longer duration of action and distributes in the cells. It also reduces the risk of liver disorders.

Indications

• Candidiasis
• Onychomycosis
• Tinea capitis
• Tinea pedis
• Sporotrichosis

Mechanism of Action

Terbinafine inhibits the squalene epoxidase thus prevents the formation of ergosterol which results in accumulation of the squalene which further leads to weakening of the fungal cell wall.

Pharmacokinetics

Absorption- It is absorbed orally
Protein Binding- It is 99% bound to proteins
Metabolism- It undergoes hydroxylation and N-demethylation
Excretion- It is excreted via urine

Side Effects

• Headache
• Rashes
• Diarrhoea
• Stomach upset
• Itching
• Nausea
• Change in taste

Drug Interactions

• Fluconazole
• Ketoconazole
• Cimetidine
• Amiodarone

Contraindication

• Contraindicated in liver disease
• Contraindicated in people with allergic to it